The rabbit is an important model species for developmental and translational research. Here, we used histological imaging and single-cell transcriptomics to characterize gastrulation and early organogenesis in the rabbit. We identified substantial transcriptional differences between the rabbit and mouse, highlighting the power of cross-species comparative genomics to elucidate early human development.
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References
Pijuan-Sala, B. et al. A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566, 490–495 (2019). This paper presents a scRNA-seq atlas of mouse gastrulation.
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This is a summary of: Ton, M.-L. N. et al. An atlas of rabbit development as a model for single-cell comparative genomics. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01174-0 (2023).
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Molecular and morphological maps of early rabbit development inform human development. Nat Cell Biol 25, 935–936 (2023). https://doi.org/10.1038/s41556-023-01175-z
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DOI: https://doi.org/10.1038/s41556-023-01175-z
