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Forced entry into the nucleus

The nuclear pore complex (NPC) regulates transport of macromolecules into and out of the nucleus. A study now shows that mechanical force applied on the nucleus affects the transport rates across the NPC diffusion barrier, modulating the nuclear localization of certain cargos.

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Fig. 1: Mechanical tuning of nucleocytoplasmic transport.


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Correspondence to André Hoelz.

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Petrovic, S., Hoelz, A. Forced entry into the nucleus. Nat Cell Biol 24, 810–812 (2022).

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