Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

REGENERATION

Defining the pathways of heart regeneration

Although cardiac cell therapy has been intensely studied, the high expectations are still an unmet goal. A study now characterizes the translational potential and mode of action of human ventricular progenitors (HVPs) derived from embryonic stem cells, as a source for cardiac cell therapy.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: The proposed mode of action of HVP-mediated cardiac cell therapy.

References

  1. Menasché, P. et al. Lancet 357, 279–280 (2001).

    Article  Google Scholar 

  2. Nguyen, P. K., Rhee, J. W. & Wu, J. C. JAMA Cardiol. 1, 831–841 (2016).

    Article  Google Scholar 

  3. Nat. Biotechnol. 35, 291 (2017).

  4. Madonna, R. et al. Eur. Heart J. 37, 1789–1798 (2016).

    Article  Google Scholar 

  5. Cai, C. L. & Molkentin, J. D. Circ. Res. 120, 400–406 (2017).

    CAS  Article  Google Scholar 

  6. Zwetsloot, P. P. et al. Circ. Res. 118, 1223–1232 (2016).

    CAS  Article  Google Scholar 

  7. Vagnozzi, R. J. et al. Nature 577, 405–409 (2020).

    CAS  Article  Google Scholar 

  8. Foo, K. S. et al. Mol. Ther. 26, 1644–1659 (2018).

    CAS  Article  Google Scholar 

  9. Poch, C. M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00899-8 (2022).

  10. Farbehi, N. et al. eLife 8, e43882 (2019).

    Article  Google Scholar 

  11. Molenaar, B. & van Rooij, E. Circ. Res. 123, 1033–1035 (2018).

    CAS  Article  Google Scholar 

  12. Chong, J. J. et al. Nature 510, 273–277 (2014).

    CAS  Article  Google Scholar 

  13. Shiba, Y. et al. Nature 538, 388–391 (2016).

    CAS  Article  Google Scholar 

  14. Liu, Y. W. et al. Nat. Biotechnol. 36, 597–605 (2018).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Eva van Rooij.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Timmer, L.T., van Rooij, E. Defining the pathways of heart regeneration. Nat Cell Biol 24, 606–607 (2022). https://doi.org/10.1038/s41556-022-00914-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-022-00914-y

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing