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CELL DEATH

RIPK1 and RIPK3 form mosaic necrosomes

Nature Cell Biology volume 24, pages 406–407 (2022)Cite this article

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Necrosomes formed by RIPK1–RIPK3 mediate necroptosis. Super-resolution microscopy identifies the architectural features of necrosomes and provides mechanistic insights into the signalling from RIPK1 to RIPK3 when RIPK1 is activated to mediate necroptosis, and from RIPK3 to RIPK1 when RIPK3 is inhibited to mediate apoptosis.

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Fig. 1: RIPK1–RIPK3 mosaic complexes in signalling for necroptosis and apoptosis.

References

  1. Degterev, A. et al. Nat. Chem. Biol. 1, 112–119 (2005).

    Article  CAS  Google Scholar 

  2. Degterev, A. et al. Nat. Chem. Biol. 4, 313–321 (2008).

    Article  CAS  Google Scholar 

  3. Mifflin, L., Ofengeim, D. & Yuan, J. Nat. Rev. Drug Discov. 19, 553–571 (2020).

    Article  CAS  Google Scholar 

  4. Meng, H. et al. Proc. Natl Acad. Sci. USA 115, E2001–E2009 (2018).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Yeh, W. C. et al. Immunity 12, 633–642 (2000).

    Article  CAS  Google Scholar 

  6. Sun, L. et al. Cell 148, 213–227 (2012).

    Article  CAS  Google Scholar 

  7. Cho, Y. S. et al. Cell 137, 1112–1123 (2009).

    Article  CAS  Google Scholar 

  8. Zhang, D. W. et al. Science 325, 332–336 (2009).

    Article  CAS  Google Scholar 

  9. Chen, X. et al. Nat. Cell Biol. s41556-022-00854-7 (2022).

  10. Zhao, J. et al. Proc. Natl Acad. Sci. USA 109, 5322–5327 (2012).

    Article  CAS  Google Scholar 

  11. Li, J. et al. Cell 150, 339–350 (2012).

    Article  CAS  Google Scholar 

  12. Mompean, M. et al. Cell 173, 1244–1253 e1210 (2018).

    Article  CAS  Google Scholar 

  13. Wu, X. et al. Proc. Natl Acad. Sci. USA 118, e2022933118 (2021).

    Article  CAS  Google Scholar 

  14. Mandal, P. et al. Mol. Cell 56, 481–495 (2014).

    Article  CAS  Google Scholar 

  15. Newton, K. et al. Science 343, 1357–1360 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

    Weiwei Qi & Junying Yuan

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  1. Weiwei Qi
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  2. Junying Yuan
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Correspondence to Junying Yuan.

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The authors declare no competing interests.

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Qi, W., Yuan, J. RIPK1 and RIPK3 form mosaic necrosomes. Nat Cell Biol 24, 406–407 (2022). https://doi.org/10.1038/s41556-022-00879-y

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