Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Metabolites control stress granule disassembly

Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Cdc19 senses metabolic state to regulate stress granule assembly.


  1. Nover, L., Scharf, K. D. & Neumann, D. Mol. Cell. Biol. 3, 1648–1655 (1983).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Storti, R. V. et al. Cell 22, 825–834 (1980).

    Article  CAS  Google Scholar 

  3. Lindquist, S. Nature 293, 311–314 (1981).

    Article  CAS  Google Scholar 

  4. Brengues, M. & Parker, R. Mol. Biol. Cell 18, 2592–2602 (2007).

    Article  CAS  Google Scholar 

  5. Protter, D. S. W. & Parker, R. Trends Cell Biol. 26, 668–679 (2016).

    Article  CAS  Google Scholar 

  6. Wolozin, B. & Ivanov, P. Nat. Rev. Neurosci. 20, 649–666 (2019).

    Article  CAS  Google Scholar 

  7. Cao, X., Jin, X. & Liu, B. Aging Cell 19, e13136 (2020).

    Article  CAS  Google Scholar 

  8. Cereghetti, G. Nat. Cell. Biol. (2021).

  9. Saad, S. et al. Nat. Cell Biol. 19, 1202–1213 (2017).

    Article  CAS  Google Scholar 

  10. Xu, Y.-F. et al. Mol. Cell 48, 52–62 (2012).

    Article  CAS  Google Scholar 

  11. Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Nat. Rev. Mol. Cell Biol. 18, 285–298 (2017).

    Article  CAS  Google Scholar 

  12. Alberti, S. & Dormann, D. Annu. Rev. Genet. 53, 171–194 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Daniel F. Jarosz.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jakobson, C.M., Jarosz, D.F. Metabolites control stress granule disassembly. Nat Cell Biol 23, 1053–1055 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing