Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

QUALITY CONTROL

Mitochondrial UPR through generations

An Author Correction to this article was published on 16 September 2021

Neuronal mitochondria perturbation elicits a mitochondrial unfolded protein response (UPRmt) in peripheral tissues cell non-autonomously, dependent on the Wnt signalling pathway. A study now reveals that a Wnt-mediated increase in maternally inherited mitochondria DNA is responsible for transgenerational UPRmt induced by neuronal mitochondria perturbation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Transgenerational induction of UPRmt mediated by increased mtDNA levels.

References

  1. 1.

    Baugh, L. R. & Day, T. eLife 9, e58498 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Perez, M. F. & Lehner, B. Nat. Cell Biol. 21, 143–151 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Moore, R. S., Kaletsky, R. & Murphy, C. T. Cell 177, 1827–1841.e2 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Klosin, A., Casas, E., Hidalgo-Carcedo, C., Vavouri, T. & Lehner, B. Science 356, 320–323 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Zhang, Q. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00724-8 (2021).

  6. 6.

    Shpilka, T. & Haynes, C. M. Nat. Rev. Mol. Cell Biol. 19, 109–120 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Berendzen, K. M. et al. Cell 166, 1553–1563.e10 (2016).

    CAS  Article  Google Scholar 

  8. 8.

    Zhang, Q. et al. Cell 174, 870–883.e17 (2018).

    CAS  Article  Google Scholar 

  9. 9.

    Gitschlag, B. L. et al. Cell Metab. 24, 91–103 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Lin, Y. F. et al. Nature 533, 416–419 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M. & Haynes, C. M. Science 337, 587–590 (2012).

    CAS  Article  Google Scholar 

  12. 12.

    Lee, S. S. et al. Nat. Genet. 33, 40–48 (2003).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Meng C. Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Park, M., Wang, M.C. Mitochondrial UPR through generations. Nat Cell Biol 23, 820–821 (2021). https://doi.org/10.1038/s41556-021-00729-3

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing