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PHF7 directs cardiac reprogramming

Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers.

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Fig. 1: Histone code reader PHF7 is a precision epigenetic regulator that increases cardiac reprogramming efficiency.


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Correspondence to Kenneth R. Chien.

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Eroglu, E., Schell, J.P. & Chien, K.R. PHF7 directs cardiac reprogramming. Nat Cell Biol (2021).

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