Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Chromatin

PHF7 directs cardiac reprogramming

Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Histone code reader PHF7 is a precision epigenetic regulator that increases cardiac reprogramming efficiency.

References

  1. 1.

    Garry, G. A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00668-z (2021).

  2. 2.

    Ieda, M. et al. Cell 142, 375–386 (2010).

    CAS  Article  Google Scholar 

  3. 3.

    Soler-Botija, C., Forcales, S. V. & Bayés Genís, A. Semin. Cell Dev. Biol. 97, 26–37 (2020).

    CAS  Article  Google Scholar 

  4. 4.

    Zhou, H. et al. Genes Dev. 31, 1770–1783 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Yang, S. Y., Baxter, E. M. & Van Doren, M. Dev. Cell 22, 1041–1051 (2012).

    CAS  Article  Google Scholar 

  6. 6.

    Wang, X. et al. Development 146, dev175547 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Srivastava, D. & DeWitt, N. Cell 166, 1386–1396 (2016).

    CAS  Article  Google Scholar 

  8. 8.

    Qin, H., Zhao, A. & Fu, X. Cell. Mol. Life Sci. 74, 3553–3575 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Godwin, J. BioEssays 36, 861–871 (2014).

    CAS  Article  Google Scholar 

  10. 10.

    Murry, C. E. & MacLellan, W. R. Science 367, 854–855 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Scott Thies, R. & Murry, C. E. Development 142, 3077–3084 (2015).

    Article  Google Scholar 

  12. 12.

    Liu, Y.-W. et al. Nat. Biotechnol. 36, 597–605 (2018).

    CAS  Article  Google Scholar 

  13. 13.

    Büning, H. & Srivastava, A. Mol. Ther. Methods Clin. Dev. 12, 248–265 (2019).

    Article  Google Scholar 

  14. 14.

    Zangi, L. et al. Nat. Biotechnol. 31, 898–907 (2013).

    CAS  Article  Google Scholar 

  15. 15.

    Chien, K. R. et al. Nat. Biotechnol. 37, 232–237 (2019).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Kenneth R. Chien.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Eroglu, E., Schell, J.P. & Chien, K.R. PHF7 directs cardiac reprogramming. Nat Cell Biol (2021). https://doi.org/10.1038/s41556-021-00684-z

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing