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Engineered myosins drive filopodial transport

Engineered, light-inducible artificial myosin motors enable selective and direct manipulation of filopodial extensions and provide refined tools to control intracellular cargo transport in vivo.

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Fig. 1: Inducible modulation of filopodial dynamics with engineered myosin motors.

References

  1. 1.

    Pröls, F., Sagar & Scaal, M. Cell. Mol. Life Sci. 73, 961–974 (2016).

    Article  Google Scholar 

  2. 2.

    Svitkina, T. Cold Spring Harb. Perspect. Biol. 10, a018267 (2018).

    Article  Google Scholar 

  3. 3.

    Zhang, Z. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-00625-2 (2020).

  4. 4.

    Schindler, T. D., Chen, L., Lebel, P., Nakamura, M. & Bryant, Z. Nat. Nanotechnol. 9, 33–38 (2014).

    CAS  Article  Google Scholar 

  5. 5.

    Kerber, M. L. & Cheney, R. E. J. Cell Sci. 124, 3733–3741 (2011).

    Article  Google Scholar 

  6. 6.

    Zhou, B. et al. J. Cell Biol. 214, 103–119 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Sahoo, P. K., Smith, D. S., Perrone-Bizzozero, N. & Twiss, J. L. J. Cell Sci. 131, jcs196808 (2018).

    Article  Google Scholar 

  8. 8.

    van Bergeijk, P., Adrian, M., Hoogenraad, C. C. & Kapitein, L. C. Nature 518, 111–114 (2015).

    Article  Google Scholar 

  9. 9.

    Nijenhuis, W., Van Grinsven, M. M. P. & Kapitein, L. C. J. Cell Biol. 219, e201907149 (2020).

    Article  Google Scholar 

  10. 10.

    Tanaka, E. M. Cell 165, 1598–1608 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Sanders, T. A., Llagostera, E. & Barna, M. Nature 497, 628–632 (2013).

    CAS  Article  Google Scholar 

  12. 12.

    Litingtung, Y., Dahn, R. D., Li, Y., Fallon, J. F. & Chiang, C. Nature 418, 979–983 (2002).

    CAS  Article  Google Scholar 

  13. 13.

    Roy, S. & Gardiner, D. M. J. Exp. Zool. 293, 186–190 (2002).

    CAS  Article  Google Scholar 

  14. 14.

    Eddy, R. J., Weidmann, M. D., Sharma, V. P. & Condeelis, J. S. Trends Cell Biol. 27, 595–607 (2017).

    CAS  Article  Google Scholar 

  15. 15.

    Abounit, S. & Zurzolo, C. J. Cell Sci. 125, 1089–1098 (2012).

    CAS  Article  Google Scholar 

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Correspondence to Jessica L. Whited.

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Erdogan, B., Whited, J.L. Engineered myosins drive filopodial transport. Nat Cell Biol 23, 113–115 (2021). https://doi.org/10.1038/s41556-021-00632-x

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