Secretory proteins undergo multiple rounds of co- and post-translational quality control checks inside the cell, but how their integrity is maintained outside the cell is an emerging topic. A study establishes a model system to investigate how the extracellular proteome is protected and integrates its findings into existing immune pathways.
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Webster, B.M., Gildea, H.K. & Dillin, A. Protein homeostasis from the outside in. Nat Cell Biol 22, 911–912 (2020). https://doi.org/10.1038/s41556-020-0534-8
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DOI: https://doi.org/10.1038/s41556-020-0534-8
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