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LCK senses asparagine for T cell activation

Amino acids are critical nutrients that contribute to metabolic and signalling pathways required to meet energy and biosynthetic demands in T cells. A new study now demonstrates that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8+ T cell activation and effector responses to pathogens and tumours.

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Fig. 1: Amino acids promote T cell activation and function.


  1. 1.

    Chapman, N. M., Boothby, M. R. & Chi, H. Nat. Rev. Immunol. 20, 55–70 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Shi, H. et al. Immunity 51, 1012–1027.e7 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Wu, J.L. Nat. Cell Biol. (2020).

  4. 4.

    Wang, W. & Zou, W. Mol. Cell 80, 384–395 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Nakaya, M. et al. Immunity 40, 692–705 (2014).

    CAS  Article  Google Scholar 

  6. 6.

    Sinclair, L. V. et al. Nat. Immunol. 14, 500–508 (2013).

    CAS  Article  Google Scholar 

  7. 7.

    Preston, G. C. et al. EMBO J. 34, 2008–2024 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Wang, R. et al. Immunity 35, 871–882 (2011).

    CAS  Article  Google Scholar 

  9. 9.

    Do, M. H. et al. J. Exp. Med. 217, e20190848 (2020).

    Article  Google Scholar 

  10. 10.

    Johnson, M. O. et al. Cell 175, 1780–1795.e19 (2018).

    CAS  Article  Google Scholar 

  11. 11.

    Xu, T. et al. Nature 548, 228–233 (2017).

    CAS  Article  Google Scholar 

  12. 12.

    Ma, E. H. et al. Cell Metab. 25, 345–357 (2017).

    CAS  Article  Google Scholar 

  13. 13.

    Leone, R. D. et al. Science 366, 1013–1021 (2019).

    CAS  Article  Google Scholar 

  14. 14.

    Wang, W. et al. Nature 569, 270–274 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Geiger, R. et al. Cell 167, 829–842.e13 (2016).

    CAS  Article  Google Scholar 

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Correspondence to Hongbo Chi.

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H.C. is a consultant for Kumquat Biosciences, Inc.

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Raynor, J.L., Chi, H. LCK senses asparagine for T cell activation. Nat Cell Biol 23, 7–8 (2021).

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