Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

IMMUNOLOGY

LCK senses asparagine for T cell activation

Amino acids are critical nutrients that contribute to metabolic and signalling pathways required to meet energy and biosynthetic demands in T cells. A new study now demonstrates that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8+ T cell activation and effector responses to pathogens and tumours.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Amino acids promote T cell activation and function.

References

  1. 1.

    Chapman, N. M., Boothby, M. R. & Chi, H. Nat. Rev. Immunol. 20, 55–70 (2020).

    CAS  Article  Google Scholar 

  2. 2.

    Shi, H. et al. Immunity 51, 1012–1027.e7 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Wu, J.L. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-00615-4 (2020).

  4. 4.

    Wang, W. & Zou, W. Mol. Cell 80, 384–395 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Nakaya, M. et al. Immunity 40, 692–705 (2014).

    CAS  Article  Google Scholar 

  6. 6.

    Sinclair, L. V. et al. Nat. Immunol. 14, 500–508 (2013).

    CAS  Article  Google Scholar 

  7. 7.

    Preston, G. C. et al. EMBO J. 34, 2008–2024 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Wang, R. et al. Immunity 35, 871–882 (2011).

    CAS  Article  Google Scholar 

  9. 9.

    Do, M. H. et al. J. Exp. Med. 217, e20190848 (2020).

    Article  Google Scholar 

  10. 10.

    Johnson, M. O. et al. Cell 175, 1780–1795.e19 (2018).

    CAS  Article  Google Scholar 

  11. 11.

    Xu, T. et al. Nature 548, 228–233 (2017).

    CAS  Article  Google Scholar 

  12. 12.

    Ma, E. H. et al. Cell Metab. 25, 345–357 (2017).

    CAS  Article  Google Scholar 

  13. 13.

    Leone, R. D. et al. Science 366, 1013–1021 (2019).

    CAS  Article  Google Scholar 

  14. 14.

    Wang, W. et al. Nature 569, 270–274 (2019).

    CAS  Article  Google Scholar 

  15. 15.

    Geiger, R. et al. Cell 167, 829–842.e13 (2016).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Hongbo Chi.

Ethics declarations

Competing interests

H.C. is a consultant for Kumquat Biosciences, Inc.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Raynor, J.L., Chi, H. LCK senses asparagine for T cell activation. Nat Cell Biol 23, 7–8 (2021). https://doi.org/10.1038/s41556-020-00621-6

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing