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CARDIAC REGENERATION

Proliferation and EMT trigger heart repair

Nature Cell Biology volume 22, pages 1291–1292 (2020)Cite this article

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Triggering heart repair after myocardial infarction is a challenge in regenerative medicine. A study now shows how ERBB2-mediated YAP activation promotes both cardiomyocyte proliferation and epithelial-to-mesenchymal transition (EMT) in adult mice. EMT initiates cardiomyocyte dedifferentiation and migration and together with proliferation promotes cardiac regeneration.

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Fig. 1: An ERBB2–YAP axis triggers CM proliferation and EMT.

References

  1. Poss, K. D., Wilson, L. G. & Keating, M. T. Science 298, 2188–2190 (2002).

    Article  CAS  Google Scholar 

  2. Porrello, E. R. et al. Science 331, 1078–1080 (2011).

    Article  CAS  Google Scholar 

  3. Aharonov, A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-00588-4 (2020).

  4. D’Uva, G. et al. Nat. Cell Biol. 17, 627–638 (2015).

    Article  Google Scholar 

  5. Xin, M. et al. Proc. Natl. Acad. Sci. USA 110, 13839–13844 (2013).

    Article  CAS  Google Scholar 

  6. Shoffner, A., Cigliola, V., Lee, N., Ou, J. & Poss, K. D. Cell Reports 32, 108089 (2020).

    Article  CAS  Google Scholar 

  7. Nieto, M. A., Huang, R. Y., Jackson, R. A. & Thiery, J. P. Cell 166, 21–45 (2016).

    Article  CAS  Google Scholar 

  8. Abnave, P. et al. Development 144, 3440–3453 (2017).

    Article  CAS  Google Scholar 

  9. Currie, J. D. et al. Biol. Open 8, bio043711 (2019).

    Article  CAS  Google Scholar 

  10. Grannas, K. et al. J. Mol. Biol. 427, 3407–3415 (2015).

    Article  CAS  Google Scholar 

  11. Oh, S. H., Swiderska-Syn, M., Jewell, M. L., Premont, R. T. & Diehl, A. M. J. Hepatol. 69, 359–367 (2018).

    Article  CAS  Google Scholar 

  12. Grande, M. T. et al. Nat. Med. 21, 989–997 (2015).

    Article  CAS  Google Scholar 

  13. Mani, S. A. et al. Cell 133, 704–715 (2008).

    Article  CAS  Google Scholar 

  14. Liu, X. et al. Nat. Cell Biol. 15, 829–838 (2013).

    Article  CAS  Google Scholar 

  15. Li, Q. et al. Nat. Commun. 8, 15166 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Instituto de Neurociencias (CSIC-UMH), Sant Joan d’Alacant, Spain

    Ainara González-Iglesias & M. Angela Nieto

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  1. Ainara González-Iglesias
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  2. M. Angela Nieto
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Correspondence to M. Angela Nieto.

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The authors declare no competing interests.

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González-Iglesias, A., Nieto, M.A. Proliferation and EMT trigger heart repair. Nat Cell Biol 22, 1291–1292 (2020). https://doi.org/10.1038/s41556-020-00594-6

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