Autophagy goes nuclear

Sirtuins are highly conserved enzymes with key roles in life extension in multiple organisms. A study now describes selective autophagic degradation of nuclear SIRT1 in senescent cells. These observations suggest that blocking sirtuin degradation could be a potential approach for anti-ageing therapies.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Sirtuin-1 lysosomal degradation in senescence/ageing.


  1. 1.

    Xu, C. et al. Nat. Cell Biol. (2020).

  2. 2.

    Imai, S. & Guarente, L. Trends Cell Biol. 24, 464–471 (2014).

    CAS  Article  Google Scholar 

  3. 3.

    Morishita, H. & Mizushima, N. Annu. Rev. Cell Dev. Biol. 35, 453–475 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    He, S. & Sharpless, N. E. Cell 169, 1000–1011 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Bonkowski, M. S. & Sinclair, D. A. Nat. Rev. Mol. Cell Biol. 17, 679–690 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Sasaki, T., Maier, B., Bartke, A. & Scrable, H. Aging Cell 5, 413–422 (2006).

    CAS  Article  Google Scholar 

  7. 7.

    Ota, H. et al. J. Mol. Cell. Cardiol. 43, 571–579 (2007).

    CAS  Article  Google Scholar 

  8. 8.

    Lee, I. H. et al. Proc. Natl. Acad. Sci. USA 105, 3374–3379 (2008).

    CAS  Article  Google Scholar 

  9. 9.

    Huang, R. et al. Mol. Cell 57, 456–466 (2015).

    CAS  Article  Google Scholar 

  10. 10.

    Dou, Z. et al. Nature 527, 105–109 (2015).

    CAS  Article  Google Scholar 

  11. 11.

    Birgisdottir, Å. B., Lamark, T. & Johansen, T. J. Cell Sci. 126, 3237–3247 (2013).

    CAS  PubMed  Google Scholar 

  12. 12.

    Chandra, T. et al. Cell Reports 10, 471–483 (2015).

    CAS  Article  Google Scholar 

  13. 13.

    Albert, S. et al. Proc. Natl. Acad. Sci. USA 114, 13726–13731 (2017).

    CAS  Article  Google Scholar 

  14. 14.

    Hayakawa, T. et al. PLoS One 10, e0116480 (2015).

    Article  Google Scholar 

  15. 15.

    Campisi, J. Cell 120, 513–522 (2005).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Toren Finkel.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tan, J.X., Finkel, T. Autophagy goes nuclear. Nat Cell Biol 22, 1159–1161 (2020).

Download citation


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing