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MEMBRANE TRAFFICKING

Clock regulation of protein secretion

The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.

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Fig. 1: The molecular clock drives circadian gene expression of clock-controlled genes.
Fig. 2: Clock control of the protein secretory pathway.

References

  1. Takahashi, J. S., Hong, H. K., Ko, C. H. & McDearmon, E. L. Nat. Rev. Genet. 9, 764–775 (2008).

    Article  CAS  Google Scholar 

  2. Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E. & Hogenesch, J. B. Proc. Natl. Acad. Sci. USA 111, 16219–16224 (2014).

    Article  CAS  Google Scholar 

  3. Chang, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0441-z (2020).

  4. Shoulders, M. D. & Raines, R. T. Annu. Rev. Biochem. 78, 929–958 (2009).

    Article  CAS  Google Scholar 

  5. Wynn, T. A. J. Clin. Invest. 117, 524–529 (2007).

    Article  CAS  Google Scholar 

  6. Woo, S. L. et al. Connect. Tissue Res. 7, 177–183 (1980).

    Article  CAS  Google Scholar 

  7. Yeung, C. Y. et al. Sci. Rep. 4, 5183 (2014).

    Article  CAS  Google Scholar 

  8. Janich, P., Arpat, A. B., Castelo-Szekely, V., Lopes, M. & Gatfield, D. Genome Res. 25, 1848–1859 (2015).

    Article  CAS  Google Scholar 

  9. Rapoport, T. A. Nature 450, 663–669 (2007).

    Article  CAS  Google Scholar 

  10. Malhotra, V. & Erlmann, P. Annu. Rev. Cell Dev. Biol. 31, 109–124 (2015).

    Article  CAS  Google Scholar 

  11. Cancino, J. et al. Dev. Cell 30, 280–294 (2014).

    Article  CAS  Google Scholar 

  12. Banushi, B. et al. Nat. Commun. 7, 12111 (2016).

    Article  CAS  Google Scholar 

  13. Novinec, M. & Lenarčič, B. Biol. Chem. 394, 1163–1179 (2013).

    Article  CAS  Google Scholar 

  14. Hirota, T. et al. Science 337, 1094–1097 (2012).

    Article  CAS  Google Scholar 

  15. Solt, L. A. et al. Nature 485, 62–68 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Thomas P. Burris.

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Burris, T.P. Clock regulation of protein secretion. Nat Cell Biol 22, 1–3 (2020). https://doi.org/10.1038/s41556-019-0449-4

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