STEM CELLS

A fine balance in tendon healing

Tendons have limited regenerative potential, and injuries often cause scarring. A study now identifies a tendon stem cell population that contributes to regeneration and a tendon fibro–adipogenic progenitor population involved in fibrosis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: A schematic of the two cell populations identified by Harvey et al. and their distinct roles in tendon healing.

References

  1. 1.

    Titan, A. L., Foster, D. S., Chang, J. & Longaker, M. T. Plast. Reconstr. Surg. 144, 639e–647e (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Juneja, S. C. & Veillette, C. A. Arthritis 2013, 154812 (2013).

    Article  Google Scholar 

  3. 3.

    Kannus, P. Scand. J. Med. Sci. Sports 10, 312–320 (2000).

    CAS  Article  Google Scholar 

  4. 4.

    Killian, M. L., Cavinatto, L., Galatz, L. M. & Thomopoulos, S. J. Shoulder Elbow Surg. 21, 228–237 (2012).

    Article  Google Scholar 

  5. 5.

    Snedeker, J. G. & Foolen, J. Acta Biomater. 63, 18–36 (2017).

    Article  Google Scholar 

  6. 6.

    Zhang, J. & Wang, J. H. Methods Mol. Biol. 1842, 217–228 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Bi, Y. et al. Nat. Med. 13, 1219–1227 (2007).

    CAS  Article  Google Scholar 

  8. 8.

    Harvey, T., Flamenco, S. & Fan, C.- M. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0417-z (2019).

  9. 9.

    Staverosky, J. A., Pryce, B. A., Watson, S. S. & Schweitzer, R. Dev. Dyn. 238, 685–692 (2009).

    CAS  Article  Google Scholar 

  10. 10.

    Chan, C. K. et al. Cell 160, 285–298 (2015).

    CAS  Article  Google Scholar 

  11. 11.

    Chan, C. K. F. et al. Cell 175, 43–56.e21 (2018).

    CAS  Article  Google Scholar 

  12. 12.

    Evrova, O. & Buschmann, J. Eur. Cell. Mater. 34, 15–39 (2017).

    CAS  Article  Google Scholar 

  13. 13.

    Hu, M. S., Moore, A. L. & Longaker, M. T. J. Invest. Dermatol. 138, 729–730 (2018).

    CAS  Article  Google Scholar 

  14. 14.

    Rinkevich, Y. et al. Science 348, aaa2151 (2015).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Michael T. Longaker.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Titan, A.L., Longaker, M.T. A fine balance in tendon healing. Nat Cell Biol 21, 1466–1467 (2019). https://doi.org/10.1038/s41556-019-0432-0

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing