Deciphering cellular heterogeneity of pancreatic tumours

Pancreatic ductal adenocarcinoma displays high levels of cellular heterogeneity, which is associated with drug resistance and high metastatic rates. A new study shows that tetraspanin CD9 marks PDAC tumour-initiating cells and functions as a regulator of glutamine metabolism.

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Fig. 1: TICs that express high surface levels of CD9 have the ability to initiate PDACs and recapitulate their cellular heterogeneity.


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Correspondence to Kivanc Birsoy.

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Zhu, X.G., Birsoy, K. Deciphering cellular heterogeneity of pancreatic tumours. Nat Cell Biol 21, 1305–1306 (2019).

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