SNXs take center stage in endosomal sorting

Endosomes are central stations for converging proteins from biosynthetic pathways and endocytic routes. Many endosomal proteins are sorted to the plasma membrane or the Golgi despite the lysosome being the primary endosomal fate. SNX5 and SNX6 are now revealed to decode a conserved bipartite signal to mediate protein sorting to the Golgi or the plasma membrane.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Schematic highlighting the sorting roles of the endosomal network.


  1. 1.

    Cullen, P. J. & Steinberg, F. Nat. Rev. Mol. Cell Biol. 19, 679–696 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Simonetti, B. et al. Nat. Cell Biol. (2019).

  3. 3.

    Xu, Y., Hortsman, H., Seet, L., Wong, S. H. & Hong, W. Nat. Cell Biol. 3, 658–666 (2001).

    CAS  Article  Google Scholar 

  4. 4.

    See, L. F. & Hong, W. Biochim. Biophys. Acta. 1761, 878–896 (2006).

    Article  Google Scholar 

  5. 5.

    Chandra, M. et al. Nat. Commun. 10, 1528 (2019).

    Article  Google Scholar 

  6. 6.

    Zimmerberg, J. & McLaughlin, S. Curr. Biol. 14, R250–R252 (2004).

    CAS  Article  Google Scholar 

  7. 7.

    Kvainickas, A. et al. J. Cell Biol. 216, 3677–3693 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Simonetti, B., Danson, C. M., Heesom, K. J. & Cullen, P. J. J. Cell Biol. 216, 3695–3712 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Elwell, C. A. et al. eLife 6, e22709 (2017).

    Article  Google Scholar 

  10. 10.

    Paul, B. et al. eLife 6, e22311 (2017).

    Article  Google Scholar 

  11. 11.

    Lucas, M. et al. Cell 167, 1623–1635.e14 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Steinberg, F. et al. Nat. Cell Biol. 15, 461–471 (2013).

    CAS  Article  Google Scholar 

  13. 13.

    Loo, L. S., Tang, N., Al-Haddawi, M., Dawe, G. S. & Hong, W. Nat. Commun. 5, 3176 (2014).

    Article  Google Scholar 

  14. 14.

    Clairfeuille, T. et al. Nat. Struct. Mol. Biol. 23, 921–932 (2016).

    CAS  Article  Google Scholar 

  15. 15.

    Suzuki, S. W. et al. J. Cell Biol. 218, 2876–2886 (2019).

    Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Wanjin Hong.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hong, W. SNXs take center stage in endosomal sorting. Nat Cell Biol 21, 1175–1177 (2019).

Download citation

Further reading


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing