NSL complex acetylates Lamin A/C

The non-specific lethal (NSL) complex is a highly conserved MOF acetyltransferase-containing complex. A recent study now shows that the NSL complex acetylates a new non-histone target, Lamin A/C and reveals the NSL complex as a crucial factor in maintaining nuclear architecture and genome integrity.

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Fig. 1: Schematic illustration of the role of the NSL complex in maintaining the stability of nuclear lamina architecture via Lamin A/C acetylation.


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Correspondence to Jerry L. Workman.

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Popova, V.V., Workman, J.L. NSL complex acetylates Lamin A/C. Nat Cell Biol 21, 1177–1178 (2019).

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