Activation of the receptor EGFR (ERBB1) occurs in response to viral infections and regulates antiviral immunity. A new study now shows that the receptor HER2 (ERBB2) negatively regulates STING signaling in response to DNA viruses and expands the model and mechanisms by which surface-receptor tyrosine kinases perform important intracellular regulatory functions.
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23 August 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Odell, I.D., Flavell, R.A. HER2 joins AKT to inhibit STING immunity. Nat Cell Biol 21, 917–918 (2019). https://doi.org/10.1038/s41556-019-0368-4
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DOI: https://doi.org/10.1038/s41556-019-0368-4
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SGLT2 inhibitor activates the STING/IRF3/IFN-β pathway and induces immune infiltration in osteosarcoma
Cell Death & Disease (2022)