Tumour vesicular micromachinery uncovered

Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin-5 complexes, thus shedding light on specific cargo packaging mechanisms.

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Fig. 1: EV biogenesis and miRNA packaging.


  1. 1.

    van Niel, G., D’Angelo, G. & Raposo, G. Nat. Rev. Mol. Cell Biol. 19, 213–228 (2018).

    Article  Google Scholar 

  2. 2.

    Minciacchi, V. R. et al. Cancer Res. 77, 2306–2317 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Zhang, H. et al. Nat. Cell Biol. 20, 332–343 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Peinado, H. et al. Nat. Rev. Cancer 17, 302–317 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Abels, E. R. & Breakefield, X. O. Cell. Mol. Neurobiol. 36, 301–312 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Latifkar, A. et al. Dev. Cell 49, 393–408.e7 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Clancy, J. W. et al. Nat. Cell Biol. (2019).

  8. 8.

    Donaldson, J. G. & Jackson, C. L. Nat. Rev. Mol. Cell Biol. 12, 362–375 (2011).

    CAS  Article  Google Scholar 

  9. 9.

    Muralidharan-Chari, V. et al. Curr. Biol. 19, 1875–1885 (2009).

    CAS  Article  Google Scholar 

  10. 10.

    Okamura, M., Inose, H. & Masuda, S. Genes (Basel) 6, 124–149 (2015).

    CAS  Article  Google Scholar 

  11. 11.

    Pellon-Cardenas, O., Clancy, J., Uwimpuhwe, H. & D’Souza-Schorey, C. Mol. Cell. Biol. 33, 2963–2975 (2013).

    CAS  Article  Google Scholar 

  12. 12.

    Stewart, M. Nat. Rev. Mol. Cell Biol. 8, 195–208 (2007).

    CAS  Article  Google Scholar 

  13. 13.

    Eva, R. et al. J. Neurosci. 32, 10352–10364 (2012).

    CAS  Article  Google Scholar 

  14. 14.

    Ghossoub, R. et al. Nat. Commun. 5, 3477 (2014).

    Article  Google Scholar 

  15. 15.

    Nolte-’t Hoen, E., Cremer, T., Gallo, R. C. & Margolis, L. B. Proc. Natl Acad. Sci. USA 113, 9155–9161 (2016).

    Article  Google Scholar 

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Correspondence to Haiying Zhang or David Lyden.

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Rodrigues, G., Zhang, H. & Lyden, D. Tumour vesicular micromachinery uncovered. Nat Cell Biol 21, 795–797 (2019).

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