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Tumour vesicular micromachinery uncovered

Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin-5 complexes, thus shedding light on specific cargo packaging mechanisms.

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Fig. 1: EV biogenesis and miRNA packaging.

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Correspondence to Haiying Zhang or David Lyden.

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Rodrigues, G., Zhang, H. & Lyden, D. Tumour vesicular micromachinery uncovered. Nat Cell Biol 21, 795–797 (2019). https://doi.org/10.1038/s41556-019-0351-0

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