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IRE1α modulates ER and mitochondria crosstalk

IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.

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The authors declare no competing interests.

Correspondence to Wolfgang F. Graier.

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Fig. 1: A novel role of IRE1α in regulating InsP3R in MAMs.