IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.
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13 September 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Malli, R., Graier, W.F. IRE1α modulates ER and mitochondria crosstalk. Nat Cell Biol 21, 667–668 (2019). https://doi.org/10.1038/s41556-019-0338-x
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DOI: https://doi.org/10.1038/s41556-019-0338-x
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