Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms.
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The authors declare no competing interests.
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Hara, M., Fukagawa, T. Centromere maintenance during DNA replication. Nat Cell Biol 21, 669–671 (2019). https://doi.org/10.1038/s41556-019-0335-0