Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Centromere maintenance during DNA replication

Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Centromeric CENP-A retention and ectopic CENP-A elimination during DNA replication.


  1. Cheeseman, I. M. Cold Spring Harb. Perspect. Biol. 6, a015826 (2014).

    Article  Google Scholar 

  2. Fukagawa, T. & Earnshaw, W. C. Dev. Cell 30, 496–508 (2014).

    Article  CAS  Google Scholar 

  3. Annunziato, A. T. Biochim. Biophys. Acta 1819, 196–210 (2013).

    Article  Google Scholar 

  4. Nechemia-Arbely, Y. et al. Nat. Cell Biol. (2019).

    Article  Google Scholar 

  5. Bodor, D. L. et al. eLife 3, e02137 (2014).

    Article  Google Scholar 

  6. Miga, K. H. et al. Genome Res. 24, 697–707 (2014).

    Article  CAS  Google Scholar 

  7. Schneider, V. A. et al. Genome Res. 27, 849–864 (2017).

    Article  CAS  Google Scholar 

  8. Maloney, K. A. et al. Proc. Natl Acad. Sci. USA 109, 13704–13709 (2012).

    Article  CAS  Google Scholar 

  9. Lacoste, N. et al. Mol. Cell 53, 631–644 (2014).

    Article  CAS  Google Scholar 

  10. Huang, H. et al. Nat. Struct. Mol. Biol. 22, 618–626 (2015).

    Article  CAS  Google Scholar 

  11. Hoffmann, S. et al. Cell Reports 17, 2394–2404 (2016).

    Article  CAS  Google Scholar 

  12. Hori, T. et al. J. Cell Biol. 216, 101–113 (2017).

    Article  CAS  Google Scholar 

  13. Hara, M., Ariyoshi, M., Okumura, E.-I., Hori, T. & Fukagawa, T. Nat. Cell Biol. 20, 1378–1388 (2018).

    Article  CAS  Google Scholar 

  14. Zasadzińska, E. et al. Dev. Cell 47, 348–362.e7 (2018).

    Article  Google Scholar 

  15. Hu, H. et al. Genes Dev. 25, 901–906 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Masatoshi Hara or Tatsuo Fukagawa.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hara, M., Fukagawa, T. Centromere maintenance during DNA replication. Nat Cell Biol 21, 669–671 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing