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Splicing the innate immune signalling in leukaemia

Nature Cell Biology volume 21, pages 536–537 (2019)Cite this article

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Components of the spliceosome are frequently mutated in haematopoietic malignancies. Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies. Now, a long isoform of IRAK4 is shown to be upregulated in a subset of acute myeloid leukaemia patients, conferring susceptibility for IRAK4 inhibition therapy.

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Fig. 1: Differential splicing of IRAK4 leads to a specific long isoform that can be therapeutically targeted.

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Authors and Affiliations

  1. Department of Pathology and Laura & Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA

    Maria Guillamot & Iannis Aifantis

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  1. Maria Guillamot
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  2. Iannis Aifantis
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Correspondence to Maria Guillamot or Iannis Aifantis.

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The authors declare no competing interests.

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Guillamot, M., Aifantis, I. Splicing the innate immune signalling in leukaemia. Nat Cell Biol 21, 536–537 (2019). https://doi.org/10.1038/s41556-019-0323-4

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