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EPIGENETICS

Memory of ancestral mitochondrial stress

Ancestral experience of mitochondrial stress is now found to render progeny of the roundworm Caenorhabditis elegans more resistant to the same insult for up to four generations. A DNA modification, N6-methyldeoxyadenine, is implicated in the inheritance of this stress adaptation.

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The authors declare no competing interests.

Correspondence to Ben Lehner.

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Fig. 1: Ancestral exposure to mitochondrial stress increases stress resistance trans-generationally in C. elegans.