BAF is a heterogenous chromatin-remodelling complex, frequently mutated in cancer. A study now defines genome-wide localization patterns of three complexes, cBAF, PBAF and previously unknown ncBAF, and reveals the ncBAF complex as a specific vulnerability in synovial sarcoma and malignant rhabdoid tumours.
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Reddy, D., Workman, J.L. Targeting BAF-perturbed cancers. Nat Cell Biol 20, 1332–1333 (2018). https://doi.org/10.1038/s41556-018-0246-5
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DOI: https://doi.org/10.1038/s41556-018-0246-5