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CENP-T bears the load in mitosis

During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

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Fig. 1: Phosphorylation-regulated kinetochore plasticity during mitosis.


  1. Musacchio, A. Curr. Biol. 25, R1002–R1018 (2015).

    Article  CAS  Google Scholar 

  2. Hara, M. & Fukagawa, T. Curr. Opin. Cell Biol. 52, 73–81 (2018).

    Article  CAS  Google Scholar 

  3. Monda, J. K. & Cheeseman, I. M. J. Cell Sci. 131, jcs.214577 (2018).

  4. Kim, S. & Yu, H. J. Cell Biol. 208, 181–196 (2015).

    Article  CAS  Google Scholar 

  5. Przewloka, M. R. et al. Curr. Biol. 21, 399–405 (2011).

    Article  CAS  Google Scholar 

  6. Screpanti, E. et al. Curr. Biol. 21, 391–398 (2011).

    Article  CAS  Google Scholar 

  7. Hara, M., Ariyoshi, M., Okumura, E., Hori, T. & Fukagawa, T. Nat. Cell Biol. (2018).

    Article  PubMed  Google Scholar 

  8. Ciferri, C. et al. Cell 133, 427–439 (2008).

    Article  CAS  Google Scholar 

  9. Petrovic, A. et al. J. Cell Biol. 190, 835–852 (2010).

    Article  CAS  Google Scholar 

  10. Petrovic, A. et al. Mol. Cell 53, 591–605 (2014).

    Article  CAS  Google Scholar 

  11. Petrovic, A. et al. Cell 167, 1028–1040 e1015 (2016).

    Article  CAS  Google Scholar 

  12. Huis In ‘t Veld, P. J. et al. eLife 5, e21007 (2016).

    Article  Google Scholar 

  13. Malvezzi, F. et al. EMBO J. 32, 409–423 (2013).

    Article  CAS  Google Scholar 

  14. Volkov, V. A., Huis In ‘t Veld, P. J., Dogterom, M. & Musacchio, A. eLife 7, e36764 (2018).

    Article  Google Scholar 

  15. Lang, J., Barber, A. & Biggins, S. eLife 7, e37819 (2018).

    Article  Google Scholar 

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Correspondence to Hongtao Yu.

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Yang, Y., Yu, H. CENP-T bears the load in mitosis. Nat Cell Biol 20, 1335–1337 (2018).

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