Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CELL CYCLE

CENP-T bears the load in mitosis

During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Phosphorylation-regulated kinetochore plasticity during mitosis.

References

  1. Musacchio, A. Curr. Biol. 25, R1002–R1018 (2015).

    Article  CAS  Google Scholar 

  2. Hara, M. & Fukagawa, T. Curr. Opin. Cell Biol. 52, 73–81 (2018).

    Article  CAS  Google Scholar 

  3. Monda, J. K. & Cheeseman, I. M. J. Cell Sci. 131, jcs.214577 (2018).

  4. Kim, S. & Yu, H. J. Cell Biol. 208, 181–196 (2015).

    Article  CAS  Google Scholar 

  5. Przewloka, M. R. et al. Curr. Biol. 21, 399–405 (2011).

    Article  CAS  Google Scholar 

  6. Screpanti, E. et al. Curr. Biol. 21, 391–398 (2011).

    Article  CAS  Google Scholar 

  7. Hara, M., Ariyoshi, M., Okumura, E., Hori, T. & Fukagawa, T. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0230-0 (2018).

    Article  PubMed  Google Scholar 

  8. Ciferri, C. et al. Cell 133, 427–439 (2008).

    Article  CAS  Google Scholar 

  9. Petrovic, A. et al. J. Cell Biol. 190, 835–852 (2010).

    Article  CAS  Google Scholar 

  10. Petrovic, A. et al. Mol. Cell 53, 591–605 (2014).

    Article  CAS  Google Scholar 

  11. Petrovic, A. et al. Cell 167, 1028–1040 e1015 (2016).

    Article  CAS  Google Scholar 

  12. Huis In ‘t Veld, P. J. et al. eLife 5, e21007 (2016).

    Article  Google Scholar 

  13. Malvezzi, F. et al. EMBO J. 32, 409–423 (2013).

    Article  CAS  Google Scholar 

  14. Volkov, V. A., Huis In ‘t Veld, P. J., Dogterom, M. & Musacchio, A. eLife 7, e36764 (2018).

    Article  Google Scholar 

  15. Lang, J., Barber, A. & Biggins, S. eLife 7, e37819 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hongtao Yu.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yang, Y., Yu, H. CENP-T bears the load in mitosis. Nat Cell Biol 20, 1335–1337 (2018). https://doi.org/10.1038/s41556-018-0241-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-018-0241-x

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing