CANCER

CRAD as a cytoskeletal tumour suppressor

β-catenin regulates cell–cell adhesion and maintains stemness through Wnt signalling, but how these functions are mechanistically related is not fully understood. A study now identifies CRAD as the mechanistic link, providing insight into how dysregulation of epithelial adhesion contributes to Wnt-driven tumorigenesis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Schematic representation of CRAD function.

References

  1. 1.

    Cancer Genome Atlas Network. Nature 487, 330–337 (2012).

    Article  Google Scholar 

  2. 2.

    Korinek, V. et al. Science 275, 1784–1787 (1997).

    CAS  Article  Google Scholar 

  3. 3.

    Nelson, W. J. Biochem. Soc. Trans. 36, 149–55 (2008).

    CAS  Article  Google Scholar 

  4. 4.

    Nelson, W. J. & Nusse, R. Science 303, 1483–1487 (2004).

    CAS  Article  Google Scholar 

  5. 5.

    Ciriello, G. et al. Cell 163, 506–519 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Hansford, S. et al. JAMA Oncol. 1, 23–32 (2015).

    Article  Google Scholar 

  7. 7.

    Jung, W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0215-z (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Edwards, M. et al. Nat. Rev. Mol. Cell Biol. 15, 677 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    Heuberger, J. & Birchmeier, W. Cold Spring Harb. Perspec. Biol. 2, a002915 (2010).

    Article  Google Scholar 

  10. 10.

    Hülsken, J., Birchmeier, W. & Behrens, J. J. Cell Biol. 127, 2061–2069 (1994).

    Article  Google Scholar 

  11. 11.

    Orsulic, S. et al. J. Cell Sci. 112, 1237–1245 (1999).

    CAS  PubMed  Google Scholar 

  12. 12.

    Huels, D. J. et al. EMBO J. 34, 2321–2333 (2015).

    CAS  Article  Google Scholar 

  13. 13.

    Beyaz, S. et al. Nature 531, 53–58 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Vermeulen, L. et al. Nat. Cell Biol. 12, 468–478 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ömer H. Yilmaz.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Eng, G., Braverman, J. & Yilmaz, Ö.H. CRAD as a cytoskeletal tumour suppressor. Nat Cell Biol 20, 1232–1233 (2018). https://doi.org/10.1038/s41556-018-0225-x

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing