CRAD as a cytoskeletal tumour suppressor

β-catenin regulates cell–cell adhesion and maintains stemness through Wnt signalling, but how these functions are mechanistically related is not fully understood. A study now identifies CRAD as the mechanistic link, providing insight into how dysregulation of epithelial adhesion contributes to Wnt-driven tumorigenesis.

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Fig. 1: Schematic representation of CRAD function.


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Correspondence to Ömer H. Yilmaz.

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Eng, G., Braverman, J. & Yilmaz, Ö.H. CRAD as a cytoskeletal tumour suppressor. Nat Cell Biol 20, 1232–1233 (2018).

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