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Differentiation keeps skin cancer at bay

The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.

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Fig. 1: Oncogenic Pik3ca biases basal progenitor cell fate towards differentiation.


  1. 1.

    Gonzales, K. A. U. & Fuchs, E. Dev. Cell 43, 387–401 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    Vogelstein, B. et al. Science 339, 1546–1558 (2013).

    CAS  Article  Google Scholar 

  3. 3.

    Ying, Z., Sandoval, M. & Beronja, S. Nat. Cell Biol. (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Fruman, D. A. et al. Cell 170, 605–635 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Sánchez-Danés, A. & Blanpain, C. Nat. Rev. Cancer 18, 549–561 (2018).

    Article  Google Scholar 

  6. 6.

    Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J. & van Deursen, J. M. EMBO Rep. 15, 1139–1153 (2014).

    CAS  Article  Google Scholar 

  7. 7.

    Gudipaty, S. A. et al. Nature 543, 118–121 (2017).

    CAS  Article  Google Scholar 

  8. 8.

    Rompolas, P. et al. Science 352, 1471–1474 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Xu, Z., Kukekov, N. V. & Greene, L. A. EMBO J. 22, 252–261 (2003).

    CAS  Article  Google Scholar 

  10. 10.

    Lyons, T. R. et al. J. Biol. Chem. 282, 21987–21997 (2007).

    CAS  Article  Google Scholar 

  11. 11.

    Kajita, M. & Fujita, Y. J. Biochem. 158, 15–23 (2015).

    CAS  Article  Google Scholar 

  12. 12.

    Brown, S. et al. Nature 548, 334–337 (2017).

    CAS  Article  Google Scholar 

  13. 13.

    Martincorena, I. et al. Science 348, 880–886 (2015).

    CAS  Article  Google Scholar 

  14. 14.

    Rognoni, E. & Watt, F. M. Trends Cell Biol. 28, 709–722 (2018).

    Article  Google Scholar 

  15. 15.

    Spira, A. I. & Carducci, M. A. Curr. Opin. Pharmacol. 3, 338–343 (2003).

    CAS  Article  Google Scholar 

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Correspondence to Panteleimon Rompolas.

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Kuri, P., Rompolas, P. Differentiation keeps skin cancer at bay. Nat Cell Biol 20, 1237–1239 (2018).

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