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Metabolic control of ferroptosis in cancer

Nature Cell Biology volume 20, pages 1104–1105 (2018)Cite this article

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Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

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Fig. 1: BAP1 enhances ferroptosis and suppresses tumorigenesis through SLC7A11.

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  1. Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

    Michael P. Murphy

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  1. Michael P. Murphy
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Correspondence to Michael P. Murphy.

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Murphy, M.P. Metabolic control of ferroptosis in cancer. Nat Cell Biol 20, 1104–1105 (2018). https://doi.org/10.1038/s41556-018-0209-x

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