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Metabolic control of ferroptosis in cancer

Ferroptosis is a regulated non-apoptotic form of cell death and its functional role in tumorigenesis remains elusive. A study now shows that the tumour suppressor BAP1 enhances ferroptosis by modulating expression of the cystine transporter SLC7A11, leading to improved control of tumour growth.

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Fig. 1: BAP1 enhances ferroptosis and suppresses tumorigenesis through SLC7A11.


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Correspondence to Michael P. Murphy.

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Murphy, M.P. Metabolic control of ferroptosis in cancer. Nat Cell Biol 20, 1104–1105 (2018).

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