News & Views | Published:

STEM CELLS

Long noncoding RNAs in gut stem cells

The intestinal crypt has become the prototype compartment to investigate adult stem cell biology, and the list of identified intestinal stem cell (ISC) markers is already extensive. A comprehensive study now uncovers an additional layer in ISC regulation by introducing long noncoding RNA lncGata6 to the stem cell repertoire.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Clevers, H. Cell 154, 274–284 (2013).

  2. 2.

    Barker, N. Nat. Rev. Mol. Cell Biol. 15, 19–33 (2014).

  3. 3.

    Vermeulen, L. & Snippert, H. J. Nat. Rev. Cancer 14, 468–480 (2014).

  4. 4.

    Sato, T. et al. Nature 459, 262–265 (2009).

  5. 5.

    Zhu, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0194-0 (2018).

  6. 6.

    Ransohoff, J. D., Wei, Y. & Khavari, P. A. Nat. Rev. Mol. Cell Biol. 19, 143–157 (2018).

  7. 7.

    Kopp, F. & Mendell, J. T. Cell 172, 393–407 (2018).

  8. 8.

    Sun, Q., Hao, Q. & Prasanth, K. V. Trends Genet. 34, 142–157 (2017).

  9. 9.

    Giakountis, A. et al. Cell Rep. 15, 2588–2596 (2016).

  10. 10.

    Gilbert, L. A. et al. Cell 154, 442–451 (2013).

  11. 11.

    Cortina, C. et al. EMBO Mol. Med. 9, 869–879 (2017).

  12. 12.

    Shimokawa, M. et al. Nature 545, 187–192 (2017).

  13. 13.

    de Sousa e Melo, F. et al. Nature 543, 676–680 (2017).

  14. 14.

    Neumann, P. et al. Nat. Commun. 9, 237 (2018).

Download references

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Pantelis Hatzis or Hugo J. G. Snippert.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: Function of intestinal stem cell specific lncGata6.