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A mitochondria–paraspeckle crosstalk

Paraspeckles are nuclear bodies built on the long noncoding RNA, NEAT1, that regulate cellular homeostasis, but how they sense and help under stress is unclear. A study now shows mitochondrial stress modulates paraspeckles by altering NEAT1 expression with a feedback loop that influences mitochondrial homeostasis.

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The author declares no competing interest.

Correspondence to Archa H. Fox.

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Fig. 1: Mechanism underlying mitochondria–paraspeckle crosstalk.