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Lysosomal catch-and-release controls mTORC1

Nature Cell Biologyvolume 20pages996997 (2018) | Download Citation

Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

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Author information

Affiliations

  1. Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA

    • Aaron M. Hosios
    •  & Brendan D. Manning

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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Brendan D. Manning.

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DOI

https://doi.org/10.1038/s41556-018-0188-y

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