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DISEASE MECHANISM

FAPs are sensors for skeletal myofibre atrophy

Skeletal muscle denervation leads to myofibre atrophy with fibrosis and fatty infiltration of muscle-resident fibroadipogenic progenitors (FAPs). A study shows that on denervation, FAPs activate pathogenic STAT3–IL-6 signalling. Inhibition of this pathway prevents atrophy and points to potential therapeutic targets.

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Fig. 1: Schematic representation of a signalling role for FAPs in response to denervation.

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Correspondence to David Sassoon.

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Marazzi, G., Sassoon, D. FAPs are sensors for skeletal myofibre atrophy. Nat Cell Biol 20, 864–865 (2018). https://doi.org/10.1038/s41556-018-0149-5

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