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XMAP215 joins microtubule nucleation team

Nature Cell Biology volume 20, pages 508–510 (2018)Cite this article

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De novo assembly of microtubules, nucleation, has remained surprisingly enigmatic, considering that microtubules are polymers of only two proteins, α- and β-tubulin, and that γ-tubulin has a well-established role as nucleator. Now, the tubulin polymerase XMAP215 is shown to be required for efficient nucleation in cooperation with γ-tubulin.

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Fig. 1: Mechanisms for activation of γ-TuRC-dependent microtubule nucleation.
Fig. 2: The synergism of γ-TuRC and XMAP215 in microtubule nucleation.

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  1. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

    Jens Lüders

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  1. Jens Lüders
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Correspondence to Jens Lüders.

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Lüders, J. XMAP215 joins microtubule nucleation team. Nat Cell Biol 20, 508–510 (2018). https://doi.org/10.1038/s41556-018-0100-9

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