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Mitochondrial OXPHOS complex assembly lines

Mitochondria are critical for cellular energy generation and house oxidative phosphorylation (OXPHOS) complexes, which are under dual genetic control. A study finds that transcript translation and complex assembly are partitioned, and OXPHOS complexes III, IV and V are built at spatially defined regions of the mitochondrial inner membrane.

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Fig. 1: Mitochondrial architecture and respiratory chain complex assembly.

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Correspondence to Michael T. Ryan.

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Formosa, L.E., Ryan, M.T. Mitochondrial OXPHOS complex assembly lines. Nat Cell Biol 20, 511–513 (2018). https://doi.org/10.1038/s41556-018-0098-z

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