How the metabolic crosstalk between cancer and stromal cells affects tumour growth is incompletely defined. MYC-activated cancer cells are now shown to secrete exosomal miR-105, which fuels tumour growth by inducing a MYC-dependent metabolic programme in cancer-associated fibroblasts.
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This work was supported by the Cancer Research Institute CLIP grant.
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Coller, H.A. MYC sets a tumour-stroma metabolic loop. Nat Cell Biol 20, 506–507 (2018). https://doi.org/10.1038/s41556-018-0096-1
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DOI: https://doi.org/10.1038/s41556-018-0096-1