CANCER

CK1α promotes tumour suppressive autophagy

The phosphatase PTEN is thought to govern tumour suppression predominantly through PI-3 kinase pathway regulation. A study now shows that a non-catalytic function of CK1α outcompetes the E3 ligase NEDD4-1 to stabilize PTEN, which activates FOXO3A-dependent ATG7 expression and stimulates tumour suppressive autophagy.

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Fig. 1: Schematic representation of CK1α-elicited regulation of FOXO3A-driven tumour suppression.

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Correspondence to Arkaitz Carracedo.

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Hermanova, I., Carracedo, A. CK1α promotes tumour suppressive autophagy. Nat Cell Biol 20, 369–371 (2018). https://doi.org/10.1038/s41556-018-0079-2

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