News & Views | Published:

NON-CODING RNA

A lncRNA GUARDINg genome integrity

Nature Cell Biologyvolume 20pages371372 (2018) | Download Citation

A coordinated DNA damage response mediated by p53 to repair DNA lesions or to promote apoptosis is essential for maintenance of genome stability. A study now unveils the long non-coding RNA GUARDIN as a component of this pathway, which protects genome integrity in a pleiotropic fashion.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Reinhardt, H. C. & Schumacher, B. Trends Genet. 28, 128–136 (2012).

  2. 2.

    Grossi, E., Sanchez, Y. & Huarte, M. Biochim. Biophys. Acta 1859, 200–208 (2016).

  3. 3.

    Hu W. L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0066-7 (2018).

  4. 4.

    Tarasov, V. et al. Cell Cycle 6, 1586–1593 (2007).

  5. 5.

    Thomson, D. W. & Dinger, M. E. Nat. Rev. Genet. 17, 272–283 (2016).

  6. 6.

    Feuerhahn, S., Chen, L. Y., Luke, B. & Porro, A. Trends Biochem. Sci. 40, 275–285 (2015).

  7. 7.

    Henderson, B. R. Bioessays 27, 884–893 (2005).

  8. 8.

    Li, M. & Yu, X. Cancer Cell 23, 693–704 (2013).

  9. 9.

    Zhang, Y. et al. Nat. Struct. Mol. Biol. 23, 522–530 (2016).

  10. 10.

    The Cancer Genome Atlas Network. Nature 490, 61–70 (2012).

  11. 11.

    Matsui, M. & Corey, D. R. Nat. Rev. Drug. Discov. 16, 167–179 (2017).

  12. 12.

    Nickoloff, J. A., Jones, D., Lee, S. H., Williamson, E. A. & Hromas, R. J. Natl. Cancer Inst. 109, djx059 (2017).

Download references

Author information

Affiliations

  1. Department of Gene Therapy and Regulation of Gene Expression, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

    • Elena Grossi
    •  & Maite Huarte
  2. Health Research Institute of Navarra (IdiSNA), Pamplona, Spain

    • Elena Grossi
    •  & Maite Huarte

Authors

  1. Search for Elena Grossi in:

  2. Search for Maite Huarte in:

Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Maite Huarte.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41556-018-0075-6

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing