ORGANELLES

Exonuclease EXD2 in mitochondrial translation

Elucidating regulation of mitochondrial mRNA translation will improve our understanding of mitochondrial function during homeostasis and disease. Ribonuclease EXD2 is now shown to be important for mitochondrial translation and oxidative phosphorylation, and its loss enhances ROS production, slows development and extends lifespan in flies.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: The exonuclease EXD2 plays an important role in mitochondrial mRNA-encoded translation, organismal ROS production and prolonged lifespan.

References

  1. 1.

    Silva, J. et al. Nat. Cell Biol., https://doi.org/10.1038/s41556-017-0016-9 (2018).

    Google Scholar 

  2. 2.

    Smogorzewska, A. et al. Mol. Cell. 39, 36–47 (2010).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Broderick, R. et al. Nat. Cell. Biol. 18, 271–280 (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Sirbu, B. M. et al. J. Biol. Chem. 288, 31458–31467 (2013).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Dziembowski, A. et al. Mol. Gen. Genet. 260, 108–114 (1998).

    CAS  Article  PubMed  Google Scholar 

  6. 6.

    Dziembowski, A. et al. J. Biol. Chem. 278, 1603–1611 (2003).

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Caballero, A. et al. Mol. Cell. 42, 390–400 (2011).

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Rea, S. L., Ventura, N. & Johnson, T. E. PLoS Biol. 5, 2312–2329 (2007).

    CAS  Article  Google Scholar 

  9. 9.

    Copeland, J. M. et al. Curr. Biol. 19, 1591–1598 (2009).

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Hsu, H. J. & Drummond-Barbosa, D. Proc. Natl Acad. Sci. USA 106, 1117–1121 (2009).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Arantes-Oliveira, N. et al. Science 295, 502–505 (2002).

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Flatt, T. et al. Proc. Natl Acad. Sci. USA 105, 6368–6373 (2008).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Brian M. Zid or Pankaj Kapahi.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zid, B.M., Kapahi, P. Exonuclease EXD2 in mitochondrial translation. Nat Cell Biol 20, 120–122 (2018). https://doi.org/10.1038/s41556-017-0031-x

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing