Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mechanopathology

Glycation-driven matrix crosslinking in cirrhosis

Nature Biomedical Engineering volume 7, pages 1343–1345 (2023)Cite this article

Subjects

Advanced glycation end products mediate the extensive crosslinking of the extracellular matrix in cirrhotic liver tissue.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Matrix crosslinking mediated by AGEs.

References

  1. Cheemerla, S. & Balakrishnan, M. Clin. Liver Dis. 17, 365–370 (2021).

    Article  Google Scholar 

  2. Afratis, N. A. et al. Matrix Biol. 68-69, 167–179 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Ortiz, C. et al. Curr. Tissue Microenviron. Rep. 2, 41–52 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Luevano-Contreras, C. & Chapman-Novakofski, K. Nutrients 2, 1247–1265 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bansode, S. et al. Sci. Rep. 10, 3397 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Fernando, D. H. et al. Int. J. Mol. Sci. 20, 5037 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lyu, C. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01019-z (2023).

    Article  PubMed  Google Scholar 

  8. Ramachandran, P. et al. Nature 575, 512–518 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Klepfish, M. et al. Front. Immunol. 11, 480 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Alrubaye, A., Motovali-Bashi, M. & Miroliaei, M. Sci. Rep. 11, 20605 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Zhao, P. et al. Adv. Sci. 10, e2203315 (2023).

    Article  Google Scholar 

  12. Sprague, L. et al. Exp. Cell Res. 323, 7–27 (2014).

    Article  CAS  PubMed  Google Scholar 

  13. Mabire, M. et al. Nat. Commun. 14, 1830 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Mohan, V., Das, A. & Sagi, I. Semin. Cancer Biol. 62, 192–200 (2020).

    Article  CAS  PubMed  Google Scholar 

  15. Adamiak, K. & Sionkowska, A. Int. J. Biol. Macromol. 161, 550–560 (2020).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel

    Orit Kollet & Irit Sagi

Authors
  1. Orit Kollet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Irit Sagi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Irit Sagi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kollet, O., Sagi, I. Glycation-driven matrix crosslinking in cirrhosis. Nat. Biomed. Eng 7, 1343–1345 (2023). https://doi.org/10.1038/s41551-023-01119-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-023-01119-w

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research