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Mechanopathology

Greater foreign-body responses to big implants

Nature Biomedical Engineering volume 7, pages 1340–1342 (2023)Cite this article

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Allometric tissue-scale stresses at an implant’s surface trigger pathological foreign-body responses, mediated by the activation of mechanoresponsive myeloid cells, that increase exponentially with body size.

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Fig. 1: Allometric tissue-scale forces can drive the FBR to implants.

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Authors and Affiliations

  1. Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Georgios Theocharidis & Aristidis Veves

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  1. Georgios Theocharidis
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  2. Aristidis Veves
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Correspondence to Aristidis Veves.

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The authors declare no competing interests.

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Theocharidis, G., Veves, A. Greater foreign-body responses to big implants. Nat. Biomed. Eng 7, 1340–1342 (2023). https://doi.org/10.1038/s41551-023-01118-x

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