Disrupting the CD47–SIRPα checkpoint in tumour macrophages and delivering a tumour-opsonizing monoclonal antibody maximizes the macrophages’ cooperative phagocytic potency.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cassetta, L. & Pollard, J. W. Nat. Rev. Drug Discov. 17, 887–904 (2018).
Kloosterman, D. J. & Akkari, L. Cell 186, 1627–1651 (2023).
Willingham, S. B. et al. Proc. Natl Acad. Sci. USA 109, 6662–6667 (2012).
Weiskopf, K. et al. Science 341, 88–91 (2013).
Weiskopf, K. Eur. J. Cancer 76, 100–109 (2017).
Bouwstra, R., van Meerten, T. & Bremer, E. Clin. Transl Med. 12, e943 (2022).
Dooling, L. J. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-023-01031-3 (2023).
Zhao, X. W. et al. Proc. Natl. Acad. Sci. USA 108, 18342–18347 (2011).
Roberts, A. W. et al. eLife 8, e45957 (2019).
Klichinsky, M. et al. Nat. Biotechnol. 38, 947–953 (2020).
Cham, L. B. et al. Cell Rep. 31, 107494 (2020).
Sockolosky, J. T. et al. Proc. Natl Acad. Sci. USA 113, E2646–2654 (2016).
Bian, Z. et al. Nat. Commun. 12, 3229 (2021).
Srivastava, R. M. et al. Clin. Cancer Res. 19, 1858–1872 (2013).
Advani, R. et al. N. Engl. J. Med. 379, 1711–1721 (2018).
Ingram, J. R. et al. Proc. Natl Acad. Sci. USA 114, 10184–10189 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
A.M. and K.W. have filed US patent applications related to macrophage-based cancer therapies via the Whitehead Institute. K.W. holds relevant patents and royalties (via Stanford University, the Whitehead Institute and Gilead Sciences), is a co-founder, scientific advisory board member and equity holder of ALX Oncology, DEM Biopharma and Solu Therapeutics, has been a scientific advisor of Carisma Therapeutics and owns stock of Ginkgo Bioworks.
Rights and permissions
About this article
Cite this article
Maoz, A., Weiskopf, K. Phagocytic cooperativity by tumour macrophages. Nat. Biomed. Eng 7, 1057–1059 (2023). https://doi.org/10.1038/s41551-023-01088-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-023-01088-0