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Therapeutic ultrasound modulates autonomic nerve pathways in diabetes

Ultrasound pulses have been used to modulate a liver–brain autonomic nerve pathway to prevent or reverse the onset of hyperglycaemia in models of diabetes in several species. The ion channel TRPA1 was shown to be essential in transducing the ultrasound stimuli within the metabolic control circuit.

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Fig. 1: Peripheral focused ultrasound stimulation (pFUS) in models of diabetes.


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This is a summary of: Cotero, V. et al. Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nat. Biomed. Eng. (2022).

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Therapeutic ultrasound modulates autonomic nerve pathways in diabetes. Nat. Biomed. Eng 6, 681–682 (2022).

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