The assessment of the performance of molecular assays would benefit from quantifying the resolution of molecular concentration — a new metric that we propose and evaluate here.
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We thank M. Tirlea and M. Sklar of the Stanford Statistics Group for helpful discussions. This work was supported by the Chan–Zuckerberg Biohub investigator program, the National Institutes of Health (NIH, OT2OD025342) and the Wu Tsai Neurosciences Institute at Stanford University.
The authors declare no competing interests.
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Nature Biomedical Engineering thanks David Duffy and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Wilson, B.D., Eisenstein, M. & Soh, H.T. Comparing assays via the resolution of molecular concentration. Nat. Biomed. Eng 6, 227–231 (2022). https://doi.org/10.1038/s41551-021-00832-8
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