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MECHANOBIOLOGY

Shear mechanosensing drives tendon adaptation

In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness and potentially improves jumping performance.

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Fig. 1: Shear mechanosensing in tenocytes regulates tendon adaptation.

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Correspondence to Spencer P. Lake.

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Eekhoff, J.D., Iannucci, L.E. & Lake, S.P. Shear mechanosensing drives tendon adaptation. Nat Biomed Eng 5, 1409–1410 (2021). https://doi.org/10.1038/s41551-021-00724-x

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