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Shear mechanosensing drives tendon adaptation

In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness and potentially improves jumping performance.

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Fig. 1: Shear mechanosensing in tenocytes regulates tendon adaptation.


  1. Ker, R. F., Bennet, M. B., Bibby, S. R., Kester, R. C. & Alexander, R. McN. Nature 325, 147–149 (1987).

    CAS  Article  Google Scholar 

  2. Arnockzy, S. P., Lavagnino, M., Whallon, J. H. & Hoonjan, A. J. Orthop. Res. 20, 29–35 (2002).

    Article  Google Scholar 

  3. Szczesny, S. E. & Elliott, D. M. Acta Biomater. 10, 2582–2590 (2014).

    CAS  Article  Google Scholar 

  4. Garvin, J., Qi, J., Maloney, M. & Banes, A. J. Tissue Eng. 9, 967–979 (2003).

    CAS  Article  Google Scholar 

  5. Lavagnino, M., Arnockzy, S. P., Tian, T. & Vaupel, Z. Connect. Tissue Res. 44, 181–187 (2003).

    CAS  Article  Google Scholar 

  6. Wall, M. & Banes, A. J. Musculoskelet. Neuronal Interact. 5, 70–84 (2005).

    CAS  Google Scholar 

  7. Coste, B. et al. Science 330, 55–60 (2010).

    CAS  Article  Google Scholar 

  8. Ranade, S. S. et al. Proc. Natl Acad. Sci. USA 111, 10347–10352 (2014).

    CAS  Article  Google Scholar 

  9. Lin, Y.-C. et al. Nature 573, 230–234 (2019).

    CAS  Article  Google Scholar 

  10. Passini, F. S. et al. Nat. Biomed. Eng. (2021).

  11. Bailey, A. J., Paul, R. G. & Knott, L. Mech Ageing Dev. 106, 1–56 (1998).

    CAS  Article  Google Scholar 

  12. Eekhoff, J. D., Fang, F. & Lake, S. P. Connect. Tissue Res. 59, 410–422 (2018).

    CAS  Article  Google Scholar 

  13. Arampatzis, A., Karamanidis, K. & Albracht, K. J. Exp. Biol. 210, 2743–2753 (2007).

    Article  Google Scholar 

  14. LeMoine, J. K., Lee, J. D. & Trappe, T. A. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R119–R124 (2009).

    CAS  Article  Google Scholar 

  15. Couppe, C. et al. Age 36, 9665 (2014).

    Article  Google Scholar 

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Correspondence to Spencer P. Lake.

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Eekhoff, J.D., Iannucci, L.E. & Lake, S.P. Shear mechanosensing drives tendon adaptation. Nat Biomed Eng 5, 1409–1410 (2021).

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