BRAIN–COMPUTER INTERFACES

From unstable input to robust output

In the presence of recording instabilities, the performance of brain–computer interfaces can be robustly maintained by exploiting ‘hidden’ structures underlying neural activity.

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Fig. 1: Patterns in the underlying activity of simultaneously recorded neurons can be leveraged to improve the robustness of decoders for BCIs.

References

  1. 1.

    Pandarinath, C. et al. eLife 6, 18554 (2017).

    Article  Google Scholar 

  2. 2.

    Collinger, J. L. et al. Lancet 381, 557–564 (2013).

    Article  Google Scholar 

  3. 3.

    Anumanchipalli, G. K., Chartier, J. & Chang, E. F. Nature 568, 493–498 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Ajiboye, A. B. et al. Lancet 389, 1821–1830 (2017).

    Article  Google Scholar 

  5. 5.

    Sussillo, D., Stavisky, S. D., Kao, J. C., Ryu, S. I. & Shenoy, K. V. Nat. Commun. 7, 13749 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Downey, J. E., Schwed, N., Chase, S. M., Schwartz, A. B. & Collinger, J. L. J. Neural Eng. 15, 046016 (2018).

    Article  Google Scholar 

  7. 7.

    Degenhart, A. D. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-020-0542-9 (2020).

  8. 8.

    Gallego, J. A., Perich, M. G., Miller, L. E. & Solla, S. A. Neuron 94, 978–984 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Sadtler, P. T. et al. Nature 512, 423–426 (2014).

    CAS  Article  Google Scholar 

  10. 10.

    Kao, J. C., Ryu, S. I. & Shenoy, K. V. Sci. Rep. 7, 7395 (2017).

    Article  Google Scholar 

  11. 11.

    Dyer, E. L. et al. Nat. Biomed. Eng. 1, 967–976 (2017).

    Article  Google Scholar 

  12. 12.

    Pandarinath, C. et al. Nat. Meth. 15, 805–815 (2018).

    CAS  Article  Google Scholar 

  13. 13.

    Farshchian, A. et al. In International Conference on Learning Representations (OpenReview.net, 2019).

  14. 14.

    Gallego, J. A., Perich, M. G., Chowdhury, R. H., Solla, S. A. & Miller, L. E. Nat. Neurosci. 23, 260–270 (2020).

    CAS  Article  Google Scholar 

  15. 15.

    Jarosiewicz, B. et al. Sci. Transl. Med. 7, 313ra179 (2015).

    Article  Google Scholar 

  16. 16.

    Oby, E. R. et al. Proc. Natl Acad. Sci. USA 116, 15210–15215 (2019).

    CAS  Article  Google Scholar 

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Correspondence to Chethan Pandarinath.

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Wimalasena, L.N., Miller, L.E. & Pandarinath, C. From unstable input to robust output. Nat Biomed Eng 4, 665–667 (2020). https://doi.org/10.1038/s41551-020-0587-9

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