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Functional extracellular vesicles aplenty

Large quantities of extracellular vesicles produced via cellular nanoporation, and loaded with endogenously transcribed therapeutic mRNAs and targeting peptides, boost therapeutic outcomes in vivo.

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Fig. 1: Strategies for loading therapeutic mRNAs into EVs.
Fig. 2: Cellular nanoporation for the enhanced production of extracellular vesicles passively loaded with therapeutic mRNAs.

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Correspondence to Samir EL Andaloussi.

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S.E.A. is a co-founder and shareholder of Evox Therapeutics Ltd., Oxford, UK. A.M.Z. declares no competing interests.

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Zickler, A.M., EL Andaloussi, S. Functional extracellular vesicles aplenty. Nat Biomed Eng 4, 9–11 (2020). https://doi.org/10.1038/s41551-019-0507-z

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