Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

COMPUTATIONAL MEDICINE

Affinity-bound antibody–drug conjugates

Computationally designed antibody–drug conjugates easily self-assemble via affinity ligands that non-covalently link a therapeutic drug to conserved sites on native IgG antibodies.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Affinity linkers for making antibody-drug conjugates.

References

  1. 1.

    Alley, S. C., Okeley, N. M. & Senter, P. D. Curr. Opin. Chem. Biol. 14, 529–537 (2010).

    CAS  Article  Google Scholar 

  2. 2.

    Ducry, L. (ed.) Antibody–drug conjugates (Springer, 2013).

  3. 3.

    Widdison, W. & Chari, R. J. in Antibody–drug conjugates and immunotoxins (ed. Phillips, G. L.) 93–115 (Springer, 2013).

  4. 4.

    Beck, A., Goetsch, L., Dumontet, C. & Corvaia, N. Nat. Rev. Drug Discov. 16, 315–337 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Christie, R. J. et al. J. Control Release 220, 660–670 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Lyon, R. P. et al. Nat. Biotechnol. 32, 1059–1062 (2014).

    CAS  Article  Google Scholar 

  7. 7.

    Panowski, S., Bhakta, S., Raab, H., Polakis, P. & Junutula, J. R. mAbs 6, 34–45 (2014).

    Article  Google Scholar 

  8. 8.

    Axup, J. Y. et al. Proc. Natl Acad. Sci. USA. 109, 16101–16106 (2012).

    CAS  Article  Google Scholar 

  9. 9.

    Li, X. et al. Bioconjug. Chem. 26, 2243–2248 (2015).

    CAS  Article  Google Scholar 

  10. 10.

    Zimmerman, E. S. et al. Bioconjug. Chem. 25, 351–361 (2014).

    CAS  Article  Google Scholar 

  11. 11.

    Badescu, G. et al. Bioconjug. Chem. 25, 1124–1136 (2014).

    CAS  Article  Google Scholar 

  12. 12.

    Gupta, N. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0470-8 (2018).

    Article  Google Scholar 

  13. 13.

    Roopenian, D. C. & Akilesh, S. Nat. Rev. Immunol. 7, 715–725 (2007).

    CAS  Article  Google Scholar 

  14. 14.

    Weiskopf, K. & Weissman, I. L. mAbs 7, 303–310 (2015).

    CAS  Article  Google Scholar 

  15. 15.

    Wang, W., Erbe, A. K., Hank, J. A., Morris, Z. S. & Sondel, P. M. Front. Immunol. 6, 368–368 (2015).

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Shawn C. Owen.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Nervig, C.S., Owen, S.C. Affinity-bound antibody–drug conjugates. Nat Biomed Eng 3, 850–851 (2019). https://doi.org/10.1038/s41551-019-0478-0

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing