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Affinity-bound antibody–drug conjugates

Computationally designed antibody–drug conjugates easily self-assemble via affinity ligands that non-covalently link a therapeutic drug to conserved sites on native IgG antibodies.

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Fig. 1: Affinity linkers for making antibody-drug conjugates.

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Correspondence to Shawn C. Owen.

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Nervig, C.S., Owen, S.C. Affinity-bound antibody–drug conjugates. Nat Biomed Eng 3, 850–851 (2019). https://doi.org/10.1038/s41551-019-0478-0

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